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Citation: Payne AG. ,’Experimental
regimen targeting the ependyma slows disease
progression in four patitents with ALS,’ Med
Hypotheses (2009), doi:10.1016/j.mehy.2008.12.032 Dr. Anthony G. Payne* Weller Health Institute and
Laboratory, 3103 South El Camino Real, E-mail: DrAGPayne@yahoo.com SUMMARY In this paper the author proposes that at
least some forms of sporadic ALS (amyotrophic lateral sclerosis) arise due to
the effects of neurotoxic compounds synthesized by
defective ependymal cells in the brain. These cells
produce cerebrospinal fluid (CSF) that is laden with neurotoxic
compounds that bring about motor neuron die-off. Evidence is garnered from
various animal studies to demonstrate the toxicity of CSF taken from ALS
patients and by virtue of the proposed mechanism (defective ependymal cells). In addition, a regimen created by the
author is introduced; a regimen that has been used by four (4) sporadic ALS
patients since 2005 resulting in what appears to be a slowing of disease
progression. All four patients have significantly outlived best estimates of
their survival tendered by their neurologists. 2009 Published by Elsevier
Ltd. |